Evidence map›Paper›PMID 41394745›Full record

ArticlebioRxiv : the preprint server for biology2025

Serial Imaging of Tumour and microEnvironment (SITE) platform for live-cell

Vaibhav Murthy, Rawan Makkawi, Francis Anderson, Carol Halsey, Elise Manalo-Hall, Sanjay Srikanth, Gabriella Tangkilisan, Ting Zheng, James McGann, Marc R Birtwistle and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vaibhav MurthyCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Rawan MakkawiCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Francis AndersonCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Carol HalseyCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Elise Manalo-HallCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Sanjay SrikanthCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Gabriella TangkilisanCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Ting ZhengCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
James McGannCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Marc R BirtwistleDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, South Carolina, USA.
Jeremy CoppermanCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Alexander E DaviesCancer Early Detection Advanced Research (CEDAR) Center, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.

Funding

High Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0M
Targeting ERK-AKT-mediated single-cell drug response heterogeneity in metastatic osteosarcomaK01OD031811 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVIES, ALEXANDER E · 2021 to 2025
$599k
NIH HHS K01 OD031811NIH HHS S10 OD034224
6 · The paper itself

Abstract

Understanding cancer initiation and progression is extremely challenging, in part due to experimental limitations in measuring and interpreting key signalling and tumour-microenvironment (TME) interactions that determine changes in cell and tissue behaviours over time. Here we developed SITE (Serial Imaging of Tumour and microEnvironment), a spatially- and temporally integrated, modular,

Indexed as

breast cancercell motilityERK signallingex vivolive imagingMarkov modellingmetastasisnicheprecision cut lung slicepulmonary metastasis assaytumour-host interactionsTumour microenvironmenttumour organoid

Identifiers

PMID41394745
PMCPMC12697362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.