Evidence map›Paper›PMID 41394741›Full record

ArticlebioRxiv : the preprint server for biology2025

Te-Hsuan Tung, Sudhagar Babu, Xiangting Tang, Alec Sciutto, Micah Romer, Prathima Racha, Victoria Fisler, Adrita Saha, Takashi Saito, Takaomi C Saido and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Te-Hsuan TungPittsburgh Institute for Neurodegenerative Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0002-0712-4861
Sudhagar BabuDepartment of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0001-6012-8936
Xiangting TangPittsburgh Institute for Neurodegenerative Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0009-0005-6891-4049
Alec SciuttoPittsburgh Institute for Neurodegenerative Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0009-0003-2187-0371
Micah RomerChildren Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Prathima RachaPittsburgh Institute for Neurodegenerative Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.
Victoria FislerPittsburgh Institute for Neurodegenerative Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0002-2113-8442
Adrita SahaDepartment of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.
Takashi SaitoDepartment of Neurocognitive Science, Institute of Brain Science, Nagoya City University, Nagoya, Aichi, Japan.ORCID 0000-0002-9659-9251
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.ORCID 0000-0003-1970-6903
Judith B GrinspanChildren Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0940-5314
Hansruedi MathysDepartment of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0003-0186-2115
Takashi D Y KozaiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-2507-3295
Franca CambiPittsburgh Institute for Neurodegenerative Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA.

Funding

Oligodendrocyte damage and dysfunction in HIV associated neurocognitive disorderR01MH098742 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI JUDITH B GRINSPAN, Kelly L Jordan-Sciutto · 2012 to 2026
$9.0M
Effects of HIV and ART on myelination in the adolescentR01MH126773 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRINSPAN, JUDITH B, JORDAN-SCIUTTO, KELLY L · 2021 to 2025
$3.9M
Using Electrical Stimulation to Modulation Microglia and the Conversion of Microglia PhenotypesR01NS115707 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOZAI, TAKASHI DANIEL YOSHIDA · 2020 to 2024
$3.2M
Subcellular Wireless Axons for in vivo Localized Neuronal ExcitationR01NS105691 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Takashi Daniel Yoshida Kozai, Wen Li · 2020 to 2026
$3.1M
Mechanisms of Oligodendrocyte Activity on Chronic Brain Implants and Recording PerformanceR01NS129632 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRANCA CAMBI, Takashi Daniel Yoshida Kozai · 2023 to 2026
$2.4M
Cognitive decline in aging and AD: neuroprotection by hypermyelination in FusOLcKOR03AG072218 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMBI, FRANCA · 2022 to 2023
$309k
NIA NIH HHS R03 AG072218NIMH NIH HHS R01 MH098742NIMH NIH HHS R01 MH126773NINDS NIH HHS R01 NS105691NINDS NIH HHS R01 NS115707NINDS NIH HHS R01 NS129632
6 · The paper itself

Abstract

Oligodendrocytes (OL) and myelin abnormalities have emerged as important contributors to the pathogenesis of Alzheimer's Disease (AD). OL maintain neuronal health through myelin axon interactions and by supplying neurotrophic and metabolic support. To gain insight on how OL and myelin may improve neuronal deficits associated with AD, we have generated a novel mouse model (AD/cKO) by crossing the App

Identifiers

PMID41394741
PMCPMC12697352

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.