Evidence map›Paper›PMID 41394669›Full record

ArticlebioRxiv : the preprint server for biology2025

Cognition Disconnected: The Influence of Domain-General Cognition (g) in Lesion-Deficit Mapping.

Lara Sozer, Joseph Griffis, Kathleen Langbehn, Joel Bruss, Emily Olafson, Kenneth Manzel, Maurizio Corbetta, Daniel Tranel, Aaron D Boes, Mark Bowren

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lara SozerDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0009-0009-4509-370X
Joseph GriffisDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0000-0002-5548-1169
Kathleen LangbehnDepartment of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0000-0001-6875-6320
Joel BrussDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0000-0003-2415-1658
Emily OlafsonClinical Imaging Group, Genentech, South San Francisco, CA 94080, United States of America.ORCID 0000-0001-8008-9516
Kenneth ManzelDepartment of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.
Maurizio CorbettaDepartment of Neuroscience, Venetian Institute of Molecular Medicine, Padova, PD 32122, Italy.ORCID 0000-0001-8295-3304
Daniel TranelDepartment of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0000-0002-1338-1389
Aaron D BoesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0000-0002-7865-9257
Mark BowrenDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America.ORCID 0000-0003-3304-6921

Funding

The Neurobiology of Social Decision-Making: Social Inference and ContextP50MH094258 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSEN, RICHARD A · 2012 to 2021
$18.6M
University of Iowam - Whole Body 7T MRI ScannerS10RR028821 · NCRR · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2010 to 2010
$8.0M
The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)T32MH019113 · NIMH · UNIVERSITY OF IOWA · PI HANNA E STEVENS, John A Wemmie · 1991 to 2026
$5.6M
Stroke, Brain Networks, and BehaviorR01NS095741 · NINDS · WASHINGTON UNIVERSITY · PI CORBETTA, MAURIZIO · 2015 to 2019
$3.0M
Predicting Cognitive Outcomes from Stroke Based on Lesion LocationR01NS114405 · NINDS · UNIVERSITY OF IOWA · PI BOES, AARON D · 2020 to 2024
$2.1M
Mechanisms of Health and Disease at the Behavioral-Biomedical InterfaceT32GM108540 · NIGMS · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K, VOSS, MICHELLE WEBB · 2014 to 2023
$1.7M
Investigating the Effects of Transcranial Magnetic Stimulation with Intracranial EEG in HumansR21MH120441 · NIMH · UNIVERSITY OF IOWA · PI BOES, AARON D, OYA, HIROYUKI · 2019 to 2020
$425k
NCRR NIH HHS S10 RR028821NIGMS NIH HHS T32 GM108540NIMH NIH HHS P50 MH094258NIMH NIH HHS R21 MH120441NIMH NIH HHS T32 MH019113NINDS NIH HHS R01 NS095741NINDS NIH HHS R01 NS114405
6 · The paper itself

Abstract

Lesion-deficit mapping is a premier technique for dissociating neural correlates of cognitive functions. However, the contribution of domain-general cognition (g) to the performance of virtually all complex behavioral tasks may encumber such efforts. This possibility has been largely unexplored. Here, we examined the influence of g in lesion-deficit mapping using a combination of structural equation modeling, lesion-behavior mapping (LBM), and structural (sLNM) and functional (fLNM) lesion network mapping. We modeled latent variables for visuospatial ability, processing speed, language, and anterograde memory among 473 patients with focal brain damage (age range 20-93, 257 men, 216 women), both with and without gassociated variance embedded within each factor. Lesion-deficit maps for domain-specific cognitive abilities were statistically significantly less spatially inter-correlated after partitioning out g (

Indexed as

General IntelligenceLanguageLesion Network MappingMemoryProcessing SpeedVisuospatial Ability

Identifiers

PMID41394669
PMCPMC12697676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.