Evidence map›Paper›PMID 41394623›Full record

ArticlebioRxiv : the preprint server for biology2025

Synthesis of stable isotope labeled analogs of phytanic acid for separate and combined tracing of alpha-, beta- and omega-oxidation.

Robert L Broadrup, Aron C Schwartz, Julia Smith, Dora von Trentini, Nathaniel W Snyder

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert L BroadrupAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University.
Aron C SchwartzDepartment of Chemistry, Haverford College.
Julia SmithDepartment of Chemistry, Haverford College.
Dora von TrentiniDepartment of Chemistry, Haverford College.
Nathaniel W SnyderAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University.ORCID 0000-0001-5643-8747

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Relevance of fatty acid handling in the adaptive response to mitochondrial dysfunctionR01DK138011 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI Erin Seifert, Nathaniel W. Snyder · 2024 to 2026
$1.6M
Measuring compartmentalized metabolism of cofactorsR35GM156596 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Nathaniel W. Snyder · 2025 to 2026
$555k
NIDDK NIH HHS R01 DK138011NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R35 GM156596
6 · The paper itself

Abstract

Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched very long chain fatty acid (VLCFA) derived in humans from the diet and catabolized via peroxisomal metabolism. Catabolism of phytanic acid is important in humans as certain inborn errors of peroxisomal metabolism, including Refsum Disease, manifest when catabolism of diet derived phytanic acid is impaired. We developed a novel, linear, unified, unoptimized synthesis of all-racemic phytanic acid along with its 2,3,6,7,10,11,14,15-d8, 1,2-

Indexed as

branched very long chain fatty acidmetabolismperoxisomePhytanic Acidstable isotope tracing

Identifiers

PMID41394623
PMCPMC12697678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.