Evidence map›Paper›PMID 41394589›Full record

ArticlebioRxiv : the preprint server for biology2025

BoltzGen: Toward Universal Binder Design.

Hannes Stark, Felix Faltings, MinGyu Choi, Yuxin Xie, Eunsu Hur, Timothy O'Donnell, Anton Bushuiev, Talip Uçar, Saro Passaro, Weian Mao and 28 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Hannes StarkMIT.
Felix FaltingsMIT.
MinGyu ChoiMIT.
Yuxin XieMIT.
Eunsu HurMIT.
Timothy O'DonnellOpen Athena.
Anton BushuievCTU Prague.
Talip UçarBoltz.
Saro PassaroBoltz.
Weian MaoMIT.
Mateo ReveizMIT.
Roman BushuievCTU Prague.
Tomáš PluskalIOCB Prague.
Josef SivicCTU Prague.
Karsten KreisNVIDIA.
Arash VahdatNVIDIA.
Shamayeeta RayIOCB Boston.
Jonathan T GoldsteinIOCB Boston.
Andrew SavinovMIT.
Jacob A HambalekUC Irvine.
Anshika GuptaUC Irvine.
Diego A Taquiri-DiazUC Irvine.
Yaotian ZhangMPI.
A Katherine HatstatUCSF.
Angelika AradaUCSF.
Nam Hyeong KimUCSF.
Ethel Tackie-YarboiUCSF.
Dylan BoselliUCSF.
Lee SchnaiderUCSF.
Chang C LiuUC Irvine.
Gene-Wei LiMIT.
Denes HniszMPI.
David M SabatiniIOCB Prague.
William F DeGradoUCSF.
Jeremy WohlwendBoltz.
Gabriele CorsoBoltz.
Regina BarzilayMIT.
Tommi JaakkolaMIT.

Funding

UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4M
Deciphering the relationship between structure, dynamics and function in helical bundle proteinsR35GM122603 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILLIAM DEGRADO · 2017 to 2026
$7.1M
Evolution and Regulation of Bacterial Proteome CompositionR35GM124732 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gene-Wei Li · 2017 to 2026
$3.8M
MATCHMAKERS - Creating and training AI tools for TCR binding prediction and designOT2CA297463 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Michael Birnbaum · 2024 to 2026
$2.6M
Probing the Rules of Protein Structure-Function Relationships through the De Novo Design of Functional ProteinsK99GM157551 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lee Schnaider · 2025 to 2026
$250k
Cytotoxicity and function of incomplete proteinsK99GM148718 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAVINOV, ANDREW · 2023 to 2024
$248k
Revealing signal transduction mechanisms through protein designK99GM155611 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATSTAT, ANNA KATHERINE · 2024 to 2025
$238k
Dual protease activated peptides for specific targetingF32GM150255 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TACKIE-YARBOI, ETHEL NAA ODEY · 2023 to 2024
$143k
NCI NIH HHS OT2 CA297463NIGMS NIH HHS F32 GM150255NIGMS NIH HHS K12 GM081266NIGMS NIH HHS K99 GM148718NIGMS NIH HHS K99 GM155611NIGMS NIH HHS K99 GM157551NIGMS NIH HHS R35 GM122603NIGMS NIH HHS R35 GM124732
6 · The paper itself

Abstract

We introduce

Identifiers

PMID41394589
PMCPMC12697729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.