Evidence map›Paper›PMID 41394571›Full record

ArticlebioRxiv : the preprint server for biology2025

Altered postnatal chromatin development in the nucleus accumbens primes lifelong stress sensitivity.

Rebekah L Rashford, Lisa Z Fang, Michael DeBerardine, Hye Ji J Kim, Laura Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Rebekah L RashfordPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Lisa Z FangDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Michael DeBerardinePrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Hye Ji J KimPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Laura HirschfieldPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Ella CerviPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Mason R BarrettDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Jeremy M ThompsonDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Meaghan C CreedDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Catherine Jensen PeñaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-2884-5035

Funding

NRSA Training Grant in Quantitative NeuroscienceT32MH065214 · NIMH · PRINCETON UNIVERSITY · PI Nathaniel Douglass Daw, KENNETH A NORMAN · 2002 to 2026
$7.9M
Epigenetic priming of response to future stressorsR01MH129643 · NIMH · PRINCETON UNIVERSITY · PI Catherine Jensen Pena · 2022 to 2026
$3.8M
Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intakeR01DA056829 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed, Vijay K Samineni · 2023 to 2026
$3.2M
Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administrationR01DA058755 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed · 2023 to 2026
$2.5M
Dissecting the role of ventral pallidal projections to nucleus accumbens in reward processingR01DA049924 · NIDA · WASHINGTON UNIVERSITY · PI CREED, MEAGHAN C · 2020 to 2024
$2.0M
Epigenetic and cellular markers of stress sensitization by early life stress in miceR00MH115096 · NIMH · PRINCETON UNIVERSITY · PI PENA, CATHERINE JENSEN · 2019 to 2021
$746k
Epigenetic and cellular markers of stress sensitization by early life stress in miceK99MH115096 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PENA, CATHERINE JENSEN · 2017 to 2018
$178k
Promoting Resilience to Early Life Stress through Epigenetic EditingF31MH131351 · NIMH · PRINCETON UNIVERSITY · PI RASHFORD, REBEKAH · 2022 to 2023
$58k
NIDA NIH HHS R01 DA049924NIDA NIH HHS R01 DA056829NIDA NIH HHS R01 DA058755NIMH NIH HHS F31 MH131351NIMH NIH HHS K99 MH115096NIMH NIH HHS R00 MH115096NIMH NIH HHS R01 MH129643NIMH NIH HHS T32 MH065214
6 · The paper itself

Abstract

Early-life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc) - a key limbic and reward-associated brain region - ELS sensitizes both cellular and transcriptional response to later stress, which are programmed by enduring epigenetic changes. Among the histone modifications persistently enriched by ELS in NAc is H3K4me1, which is associated with open chromatin and epigenetic priming of genomic enhancers. Here, we sought to determine whether H3K4me1 enrichment in NAc was sufficient to prime cellular and behavioral responses to adult stress. Viral-mediated overexpression of the histone H3 monomethyltransferase

Identifiers

PMID41394571
PMCPMC12697533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.