ArticlebioRxiv : the preprint server for biology2025
Connectivity and phenotype of vasopressin 1a receptor cells in the lateral septum.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The neuropeptide arginine-vasopressin (AVP) regulates sexually-differentiated social behaviors, including sexual behavior, aggression, and social communication. Much of AVP's effect on social behavior is mediated by the most widely-expressed AVP receptor in the central nervous system: the vasopressin 1a receptor (V1aR). Dense expression of V1aR is found in males and females in the lateral septum (LS), which also receives heavy input from sexually-differentiated populations of AVP cells in the extended amygdala. In order to access and interrogate the structure and function of V1aR cells, we developed and validated a V1aR-Cre knockin mouse line (Avpr1a-P2A-iCre). V1aR-Cre mice did not differ from their Cre-negative littermates in their health, sensorimotor function, anxiety/motivational behavioral responses, or in their V1aR binding levels in the LS. The distribution of Cre in the brain, as assessed by crosses with Cre-reporter mouse lines and
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