ArticlebioRxiv : the preprint server for biology2025
Optogenetic stimulation of memory-tagged neurons elicits endogenous patterns of neural activity.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Hippocampal neurons encoding memories discharge in sparsely-distributed patterns; they can be optogenetically tagged, then photostimulated to elicit conditioned behavior, potentially generating a synthetic memory trace, "engram". We investigated mouse hippocampal population responses to the photostimulation of memory-tagged neurons to determine if memory-associated discharge is mimicked in hippocampus, a network with non-linear and homeostatic interactions. Both memory-tagged and not-tagged CA1 cells adjusted firing during photostimulation without altering place cell firing fields. Cell-pair cofiring relationships also maintain during photostimulation, indicating a low-dimensional, dynamical structure-preserving, homeostatic network response instead of the photostimulated pattern. Photostimulating neurons that were tagged during place-avoidance memory elicits similar place-avoidance memory in control conditions. Thus artificial photostimulation elicits natural, stored, homeostatic neuronal network cofiring patterns to elicit memory, establishing mimicry evidence for the engram.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.