Evidence map›Paper›PMID 41394546›Full record

ReviewFood science & nutrition2025

Effects and Mechanisms of Dietary Natural Products on Ischemic Stroke: An Updated Review.

Kai-Yi Zhong, Yong Zhang, Nai-Dong Wang, Guang-Wen Li, Xian-Jun Zhang, Zhi-Jun Yang

Abstract readReview
In one paragraph

Review in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai-Yi ZhongDepartment of Neurology The Affiliated Hospital of Qingdao University Qingdao China.
Yong ZhangDepartment of Neurology The Affiliated Hospital of Qingdao University Qingdao China.
Nai-Dong WangDepartment of Neurology The Affiliated Hospital of Qingdao University Qingdao China.
Guang-Wen LiDepartment of Neurology The Affiliated Hospital of Qingdao University Qingdao China.
Xian-Jun ZhangDepartment of Neurology The Affiliated Hospital of Qingdao University Qingdao China.
Zhi-Jun YangInstitute of Fruit Tree Research, Guangdong Academy of Agricultural Sciences, Key Laboratory of South Subtropical Fruit Biology and Genetic Resource Utilization, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Science and Technology Research on Fruit Tree Guangzhou China.ORCID https://orcid.org/0009-0005-7287-7973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke ranks among the primary contributors to mortality and prolonged disability globally, representing a significant public health challenge. Some clinical drugs for the treatment of ischemic stroke have significant side effects. Therefore, exploring effective therapeutic strategies is crucial. Some dietary natural products, such as fruits, vegetables, teas, herbs, nuts, probiotics and prebiotics, exert potential neuroprotective effects on ischemic stroke. The underlying mechanisms of action include suppressing oxidative stress, inhibiting inflammation, alleviating excitotoxicity, promoting angiogenesis, protecting blood-brain barrier, regulating gut microbiota, attenuating apoptosis, inhibiting autophagy, suppressing platelet aggregation and thrombosis, and improving mitochondrial function. This review mainly summarizes recent advancements in the potential therapeutic effects and mechanisms of dietary natural products on ischemic stroke. Additionally, it highlights future research directions, including the synergistic effects of combining dietary natural products, as well as the incorporation of nanotechnology to enhance bioavailability and targeted delivery. Overall, this review provides a useful reference for the application of dietary natural products in the prevention and management of ischemic stroke.

Indexed as

dietary natural productsgut microbiotainflammationischemic strokemolecular mechanismsneuroprotection

Identifiers

PMID41394546
PMCPMC12696334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.