Evidence map›Paper›PMID 41394542›Full record

ArticleFood science & nutrition2025

Red Wine May Mitigate the Risk of Intracerebral Hemorrhage by Preventing Hypertension-A Mendelian Randomization Study Combining CHARLS.

Fuan Zhang, Ning Ding, Lanying Zhang, Ping Zhang, Rui Liu, Ziqiang Chen, Jiao Chen, Huanhuan Li, Shengtao Yao

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fuan ZhangDepartment of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Ning DingDepartment of Neurosurgery and Key Laboratory of Neurotrauma Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
Lanying ZhangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Ping ZhangDepartment of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Rui LiuDepartment of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Ziqiang ChenDepartment of Neurosurgery and Key Laboratory of Neurotrauma Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
Jiao ChenDepartment of Neurosurgery and Key Laboratory of Neurotrauma Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
Huanhuan LiDepartment of Neurosurgery and Key Laboratory of Neurotrauma Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
Shengtao YaoDepartment of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.ORCID https://orcid.org/0000-0002-6564-2261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although alcohol is viewed as a risk factor for intracerebral hemorrhage, the causal relationship between different types of alcoholic beverages and intracerebral hemorrhage remains unclear, representing a significant gap in the field of intracerebral hemorrhage prevention. This study aims to fill this gap by investigating how daily drinking habits can help prevent intracerebral hemorrhage. Alcohol, red wine, and white wine were selected to conduct two-sample Mendelian randomization analyses to investigate their associations with intracerebral hemorrhage. Positive results (alcohol, red wine) were further analyzed using multivariable Mendelian randomization to distinguish independent effects. Additionally, hypertension, a risk factor for intracerebral hemorrhage, was utilized for mediation Mendelian randomization analysis to preliminarily explore the mechanisms by which exposure factors influence intracerebral hemorrhage outcomes. Finally, the conclusions were validated in the Chinese population using the CHARLS database and extended the findings. Alcohol was found to be a risk factor (OR = 1.21,

Indexed as

alcohol intakehypertensionintracerebral hemorrhageMendelian randomizationpredictive, preventive, personalized medicinered wine intake

Identifiers

PMID41394542
PMCPMC12701324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.