Evidence map›Paper›PMID 41394535›Full record

ArticleCHEST critical care2025

Epidemiologic Characteristics and Management of Sepsis Among Previously Healthy Patients.

Rachel K Hechtman, Megan E Heath, Jennifer K Horowitz, Elizabeth McLaughlin, Patricia J Posa, John Blamoun, Paul Bozyk, Megan Cahill, Rania Esteitie, Kevin Furlong and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CHEST critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Rachel K HechtmanDepartment of Internal Medicine, University of Michigan.
Megan E HeathDepartment of Internal Medicine, University of Michigan; The Michigan Hospital Medicine Safety Consortium Coordinating Center.
Jennifer K HorowitzDepartment of Internal Medicine, University of Michigan; The Michigan Hospital Medicine Safety Consortium Coordinating Center.
Elizabeth McLaughlinDepartment of Internal Medicine, University of Michigan; The Michigan Hospital Medicine Safety Consortium Coordinating Center.
Patricia J PosaDepartment of Internal Medicine, University of Michigan.
John BlamounDepartment of Medicine, MyMichigan Health, Midland.
Paul BozykDivision of Pulmonology and Critical Care Medicine, Corewell Health, Royal Oak.
Megan CahillDepartment of Emergency Medicine, Henry Ford Macomb, Macomb.
Rania EsteitieDepartment of Pulmonary and Critical Care, Covenant HealthCare, Saginaw.
Kevin FurlongDepartmet of Internal Medicine, University of Michigan Health - West, Wyoming.
Namita JayaprakashDepartment of Emergency Medicine, Henry Ford Hospital, Henry Ford Health, Detroit.
Jessica JonesCorewell Health, Dearborn.
Maximiliano Tamae-KakazuDivision of Pulmonary and Critical Care Medicine, Corewell Health, Grand Rapids.
Joan NagelkirkDepartment of Internal Medicine, Trinity Health, Muskegon.
Thomas PfotenhauerDepartment of Hospital Medicine, Holland Hospital, Holland, MI.
Derek C AngusDepartment of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Scott A FlandersDepartment of Internal Medicine, University of Michigan.
Elizabeth S MunroeDepartment of Internal Medicine, University of Michigan.
Hallie C PrescottDepartment of Internal Medicine, VA Center for Clinical Management Research, Ann Arbor.

Funding

PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M
NCATS NIH HHS L30 TR005867NHLBI NIH HHS T32 HL007749
6 · The paper itself

Abstract

backgroundMost deaths resulting from sepsis occur among patients with advanced age, multiple morbidities, or frailty. It is unclear how many sepsis-related deaths truly are preventable. Previously healthy patients may provide insight into preventable sepsis mortality. RESEARCH QUESTION: What are the baseline characteristics, management, and outcomes associated with previously healthy patients with sepsis? STUDY DESIGN AND

methodsThis was a retrospective cohort of patients hospitalized for community-onset sepsis at 66 Michigan hospitals (November 2020-January 2024). We developed major and minor criteria to classify patients as previously healthy vs having significant comorbidities. We compared baseline characteristics, management, and outcomes of previously healthy patients vs patients with comorbid sepsis. Physicians reviewed charts of previously healthy patients with in-hospital death to evaluate baseline health status and rate preventability of death.

resultsOf 29,688 patients hospitalized for sepsis, 2,963 patients (10.0%) were classified as previously healthy. Previously healthy patients had median age of 53 years, a median of 2 minor comorbidities, and lower in-hospital mortality (5.8% vs 12.7%;

interpretationWe found that 1 in 10 patients with community-onset sepsis was healthy previously. Although gaps in in-hospital management were identified, deaths among previously healthy patients generally were deemed unpreventable with better in-hospital management because of patients seeking treatment too late in the course of sepsis. This study highlights system-level opportunities for better recognition and triage of sepsis before hospitalization.

Indexed as

comorbidityepidemiologyhospitalizationinfectionmortality

Identifiers

PMID41394535
PMCPMC12700642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.