Evidence map›Paper›PMID 41394506›Full record

ArticleBiomedical optics express2025

Convolutional neural network-based differentiation of intraocular inflammatory cells with ultrahigh-resolution OCT.

Jiachi Hong, Siyu Chen, Amy Pohodich, Tejpal Gill, Xubo Song, Yifan Jian, Eric Suhler, David Huang, Yan Li

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in ophthalmology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiachi HongCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-4862-2928
Siyu ChenCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-0336-3627
Amy PohodichCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.
Tejpal GillDivision of Arthritis and Rheumatic Diseases, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Xubo SongDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA.
Yifan JianCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.
Eric SuhlerCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.
David HuangCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-2592-8393
Yan LiCasey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-7884-8074

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Applications of ultrahigh-speed long-range wide-field OCT in anterior eye diseasesR01EY028755 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HUANG, DAVID · 2018 to 2022
$2.5M
Quantification and Classification of Aqueous and Vitreous Inflammation in Uveitis Using Deep Learning Analysis of Ultrahigh-Resolution OCTR21EY036563 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, YAN · 2024 to 2025
$404k
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY028755NEI NIH HHS R21 EY036563
6 · The paper itself

Abstract

The differential diagnosis of uveitis is broad and often challenging. A key indicator of intraocular inflammation is the presence of cells in the aqueous or vitreous humor. We developed a lightweight convolutional neural network (CNN) model capable of classifying intraocular inflammatory cell types using ultrahigh-resolution optical coherence tomography (OCT). The model was trained and optimized using OCT images of known cell types-mononuclear cells and granulocytes-and achieved an accuracy of 88.4 ± 0.6%, with an area under the receiver operating characteristic (ROC) curve of 94.3 ± 0.4%. The inflammatory cell compositions predicted by the model were consistent with clinical diagnoses in uveitis patients. This approach offers a promising tool for the diagnosis and monitoring of intraocular inflammation in uveitis.

Identifiers

PMID41394506
PMCPMC12698106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.