Evidence map›Paper›PMID 41394499›Full record

ArticleBiomedical optics express2025

NO-ergic mechanisms of age differences in photostimulation of lymphatic drainage, filtration, and clearance.

Anastasiia Semyichkina-Glushkovskaia, Inna Blokhina, Ivan Fedosov, Alexander Shirokov, Maria Tsoy, Alexander Dubrovsky, Alexander Dmitrenko, Andrey Terskov, Daria Zlatogorskaya, Viktoria Adushkina and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Anastasiia Semyichkina-GlushkovskaiaDepartment of Computer Science and Information Technology, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Inna BlokhinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID https://orcid.org/0000-0003-1517-0857
Ivan FedosovInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander ShirokovDepartment of Computer Science and Information Technology, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.ORCID https://orcid.org/0000-0003-4321-735X
Maria TsoyInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DubrovskyInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DmitrenkoDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Andrey TerskovDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Daria ZlatogorskayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Viktoria AdushkinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Arina EvsukovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Matvey TuzhilkinDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Inna ElizarovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Anastasiia KalabukhovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Egor IlyukovMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Advanced 13 Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Dmitry MyagkovInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Dmitry TuktarovInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Sergey PopovInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Timophey InozemcevInstitute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Oxana Semyachkina-GlushkovskayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Jürgen KurthsResearch Institute of Intelligent Complex Systems, Fudan University, 220 Handan Rd, Yangpu District, 200437 Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photobiomodulation (PBM) is recognized as a promising, noninvasive, and safe therapy for brain diseases. However, age is a limiting factor for effective phototherapy of brain pathology. The mechanisms of decreasing efficiency of therapeutic effects of PBM in the aging brain remain poorly understood. Recently, it has been shown that PBM of brain lymphatic drainage by stimulation of the nitric oxide (NO) production in the lymphatic endothelium plays a key role in the PBM-therapy of brain diseases. In this study, we clearly show that PBM increases the NO production in the lymphatic endothelial cells and the contractility of the afferent (drainage function) and efferent (filtration function) cervical lymphatic vessels (cLVs), which is significantly suppressed after the NO blockade in 3- and 12-month-old mice. However, 24-month-old mice are insensitive to both factors, PBM and its suppression by the NO blockade. In old mice, a decrease in sensitivity to PBM is associated with age-related lymphatic endothelium dysfunction, including changes in the cLV morphology (hyperplasia), a decrease in the NO production, and the contractility of cLVs, leading to reduced lymphatic removal of beta amyloid from the brain. These results suggest that the combined therapy, including PBM with an increase in NO production in the lymphatic endothelium, can substantially improve the effectiveness of the stimulating effects of PBM on brain drainage and the removal of toxic metabolites from its tissues, which might generally contribute to improving phototherapy of brain diseases in the elderly.

Identifiers

PMID41394499
PMCPMC12698080

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