Evidence map›Paper›PMID 41394484›Full record

ArticleBiomedical optics express2025

Wide-field cellular-resolution retinal imaging using deformable mirror-based sensorless adaptive optics time-domain full-field OCT.

Yao Cai, Olivier Martinache, Maxime Bertrand, Clémentine Callet, Olivier Thouvenin, Kate Grieve, Pedro Mecê

Abstract read
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Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yao CaiInstitut Langevin, ESPCI Paris, CNRS, PSL University, Paris, France.ORCID https://orcid.org/0000-0002-9468-6001
Olivier MartinacheInstitut Langevin, ESPCI Paris, CNRS, PSL University, Paris, France.
Maxime BertrandSharpEye SAS, Gentilly, France.ORCID https://orcid.org/0000-0002-5812-6955
Clémentine CalletSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
Olivier ThouveninInstitut Langevin, ESPCI Paris, CNRS, PSL University, Paris, France.ORCID https://orcid.org/0000-0003-4853-7555
Kate GrieveSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
Pedro MecêInstitut Langevin, ESPCI Paris, CNRS, PSL University, Paris, France.ORCID https://orcid.org/0000-0001-7685-3999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adaptive optics (AO) enables cellular-resolution retinal imaging by correcting ocular aberrations, but its widespread clinical adoption remains limited by the narrow field of view (FOV) imposed by the isoplanatic patch of the eye. In this study, we present a deformable mirror (DM)-based sensorless AO time-domain full-field OCT (FFOCT) system that overcomes these limitations by leveraging the inherent robustness of FFOCT to ocular aberrations under spatially incoherent illumination. Using both phantom eye simulations and in vivo experiments, we demonstrate that correction of only three to five Zernike modes (defocus, astigmatism, and coma) is sufficient to significantly enhance SNR and resolve fine retinal structures. This includes reliable visualization of cone photoreceptors as close as 0.3

Identifiers

PMID41394484
PMCPMC12698103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.