Evidence map›Paper›PMID 41394473›Full record

ArticleFrontiers in allergy2025

Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid-based formula during early life: results of a randomized controlled trial (PRESTO study).

Pantipa Chatchatee, Annelot C Breedveld, Simone R B M Eussen, Anna Nowak-Wegrzyn, Lars Lange, Suwat Benjaponpitak, Kok Wee Chong, Pasuree Sangsupawanich, Harm Wopereis, Manon M Oude Nijhuis and 10 more

Abstract read
In one paragraph

Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Pantipa ChatchateeCenter of Excellence for Allergy and Clinical Immunology, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Annelot C BreedveldDanone Research & Innovation, Utrecht, Netherlands.
Simone R B M EussenDanone Research & Innovation, Utrecht, Netherlands.
Anna Nowak-WegrzynAllergy and Immunology, Department of Pediatrics, New York University Langone Health, New York, NY, United States.
Lars LangeSt Marien Hospital, Bonn, Germany.
Suwat BenjaponpitakThe Pediatric Allergy and Immunology Division, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Kok Wee ChongThe Allergy Service, Department of Paediatric Medicine, KKWomen's & Children's Hospital, Singapore, Singapore.
Pasuree SangsupawanichThe Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Harm WopereisDanone Research & Innovation, Utrecht, Netherlands.
Manon M Oude NijhuisDanone Research & Innovation, Utrecht, Netherlands.
Jane E LangfordDanone Research & Innovation, Utrecht, Netherlands.
Atanaska I KostadinovaDanone Research & Innovation, Utrecht, Netherlands.
Valerie TrendelenburgThe Department of Pediatric Pneumology, Immunology, and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Robert PesekArkansas Children's Hospital, Little Rock, AR, United States.
Carla M DavisTexas Children's Hospital, Baylor College of Medicine, Houston, TX, United States.
Antonella MuraroThe Food Allergy Referral Centre, Padua University Hospital, Padua, Italy.
Michel Erlewyn-LajeunesseUniversity Hospital Southampton, Southampton, United Kingdom.
Adam T FoxGuy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Louise J MichaelisGreat North Children's Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.
Kirsten BeyerThe Department of Pediatric Pneumology, Immunology, and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consumption of an amino acid-based formula (AAF) with added synbiotics [short-chain oligofructose and long-chain inulin (scFOS/lcFOS, 9:1 ratio) and

Indexed as

amino acid-based formulacow's milk protein allergymicrobiotaoral tolerance developmentprebioticsprobioticsshort chain fatty acidssynbiotics

Identifiers

PMID41394473
PMCPMC12695744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.