ArticleIndian journal of orthopaedics2025
Bone Marrow Aspirate Concentrate (BMAC) Versus Adipose-Derived Stem Cells (ADSCs) Intra-articular Injection Therapeutic Efficacy in Knee OA Correlated to Their Mesenchymal Stem Cell (MSC) Cellularity: An Exploratory Comparative Pilot Study.
Article in Indian journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Mesenchymal stromal cells therapy for remodeling the joint microenvironment: mechanisms, nanotechnology-enhanced strategies, and translation prospects.Stem cell research & therapy · 2026Review
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6 authors.
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Abstract
Background: Osteoarthritis (OA) is a chronic degenerative joint disease affecting millions of people mainly aged over 65. OA leads to progressive damage across joint components, including bone degeneration with osteophyte formation, cartilage erosion, synovitis, and meniscal deterioration. Early OA treatments focus on symptom management, but advanced knee OA often requires alternative approaches. Regenerative medicine, such as tissue engineering, offers promising solutions. Mesenchymal stem cell (MSC) intra-articular injections have gained popularity for OA management. Autologous sources, such as bone marrow aspirate concentrate (BMAC) and adipose-derived stem cells (ADSCs), are widely used. Objective: This study compared the therapeutic efficacy of single BMAC and ADSC injections in knee OA patients, focusing on MSC quantity and quality in harvested tissues. To support this, hematological studies analyzed and quantified CD34+ cells in adipose and bone marrow samples. Methods: 60 patients diagnosed with symptomatic degenerative knee OA were enrolled. Patients under 50 received BMAC injections, while those over 50 received ADSC injections. Follow-ups were conducted at baseline(t0), 1 month (t1), 3 months (t2), and 6 months (t3) using the Visual Analog Scale (VAS), WOMAC score, Kellgren-Lawrence classification, and range of motion (ROM). Bone marrow and adipose samples were harvested and processed to quantify viable MSCs. Mononuclear cells were isolated using density gradient centrifugation, and CD34+ cells were subsequently enriched through magnetic separation using column-based processing. Cultured MSCs were counted weekly to evaluate proliferation. Results: Both groups showed significant clinical improvements in VAS, WOMAC, and ROM scores ( Conclusions: At 6 months, both BMAC and ADSC treatments resulted in significant clinical improvements ( Graphical abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s43465-025-01525-z.
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