ArticleF1000Research2025
Vitamin D binding protein rs7041 and rs4588 gene polymorphisms in Ugandan tuberculosis patients and household contacts: A pilot study.
Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Tuberculosis remains a significant global public health concern. Genetic variants influence the distribution of vitamin D in circulation, leading to vitamin D deficiency. The two extensively studied non-synonymous D-binding protein nucleotide polymorphisms rs7041 and rs4588 were found in different populations. These polymorphisms result into three different genotypes, Gc1F (rs7041(A)- rs4588(G)), Gc1S (rs7041(C)- rs4588(G)) and Gc2 (rs7041(A)- rs4588(T)). These genotypes have configurational changes that differ and therefore cause variation in the binding affinity of the vitamin D metabolite. This study aimed to compare the frequency distribution of vitamin D binding protein gene polymorphisms in patients with active Ugandan tuberculosis, individuals with latent tuberculosis infection, and those with no tuberculosis infection. Methods: This pilot studyselected 102 samples, including 52 active tuberculosis patients, 23 latent tuberculosis individuals, and 27 individuals without tuberculosis infection, from a previous cross-sectional study. Vitamin D binding protein rs7041 and rs4588 SNPs were genotyped using Polymerase Chain Reaction and Sanger sequencing. Vitamin D binding protein gene polymorphisms were identified using BioEdit software. 7.2 ( http://www.mbio.ncsu.edu/BioEdit/bioedit.html). Results: This study revealed no significant differences in DBP genetic polymorphisms among the study groups. The frequency distribution of the DBP gene has been reported to be 97% Gc1F, 2% Gc2, and 1% Gc1S. The frequency distribution among patients with TB was 96.2% for Gc1F, 0% for Gc1F, and 3.8% for Gc2. Among the LTBI cases, 95.7% were Gc1F, 4.3% were Gc1S, and 0%were Gc2. The Hardy-Weinberg equilibrium analysis was in equilibrium, D'= 0. P=0.2. Conclusions: The Gc1F genotype was predominantly found in the study population, with no difference in the frequency distribution according to TB status.
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