ArticleFrontiers in cell and developmental biology2025
Hypertensive disorders of pregnancy increase neonatal cerebral regional tissue oxygen saturation in the early postnatal period: partial mediation by preterm birth.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Hypertensive disorders of pregnancy (HDP) are closely related to placental disfunction and may association neonatal cerebral oxygenation. This study aimed to assess the correlation of maternal HDP on neonatal cerebral regional tissue oxygen saturation (crSO Methods: An observational case-control study enrolled 16799 newborns as the basis for subsequent screening. Finally, 464 infants born to mothers exposed to HDP were selected as the case group, and 464 normal mothers were selected as the control group. Cerebral oxygenation was monitored weekly using near-infrared spectroscopy from birth until 28 days postnatally or discharge. crSO Results: Neonates exposed to maternal HDP/preeclampsia showed significantly higher crSO Conclusion: Maternal HDP is associated with elevated neonatal cerebral oxygenation and reduced cerebral oxygen extraction in the early postnatal period. These associations are partially mediated by preterm birth, which may be linked to impaired placental function in pregnancies complicated by HDP.
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