ArticleCardiovascular endocrinology & metabolism2026
Genetic evidence for the causal relationship between metabolic diseases and primary aldosteronism: insights from Mendelian randomization analysis.
Article in Cardiovascular endocrinology & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Endocrine society 2025 diagnostic criteria increase primary aldosteronism detection in hypertensive patients: a comparative study with 2016 guidelines.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
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4 authors.
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Abstract
Purpose: Although the relationship between metabolic diseases and primary aldosteronism has been recognized for years, the causal relationship between them remains unclear. Therefore, our study aimed to clarify this uncertainty. Methods: Mendelian randomization analysis was performed to explore potential causal links between metabolic diseases and primary aldosteronism. Next, we conducted a mediator analysis to explore the role of plasma proteins in the relationship between metabolic diseases and primary aldosteronism. Finally, phenome-wide association studies (Phe-WAS) were conducted to explore the relationship between primary aldosteronism and other diseases. Results: Genetically predicted some metabolic diseases are significantly causally associated with primary aldosteronism, including type 2 diabetes mellitus [odds ratio (OR): 1.20, 95% confidence interval (CI): 1.05-1.37, Conclusion: This study provides genetic evidence suggesting that certain metabolic diseases may increase the risk of primary aldosteronism, highlighting the necessity of enhanced primary aldosteronism screening and prevention in patients with metabolic disorders.
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