Evidence map›Paper›PMID 41394327›Full record

ArticleChem2024

Convergent Synthesis and Protein Binding of Vicinal Difluorides by Stereodivergent C-C Bond Formation.

Yehao Qiu, Vienna C J X Thomas, Tommaso Fantoni, Reichi Chen, Xingyu Jiang, Zhi-Tao He, Trevor W Butcher, Daniel K Nomura, John F Hartwig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Stereodivergent CspChemical science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yehao QiuDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Vienna C J X ThomasDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Tommaso FantoniDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Reichi ChenDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Xingyu JiangDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Zhi-Tao HeDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Trevor W ButcherDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
Daniel K NomuraDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.
John F HartwigDepartment of Chemistry, University of California, Berkeley, California, 94720, United States.

Funding

Tackling Undruggable Cancer Targets using Chemoproteomic PlatformsR35CA263814 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Daniel Nomura · 2022 to 2026
$4.6M
A proposal for the purchase of a new Cu anode Microsource X-ray Diffractometer wiS10RR027172 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAYMOND, KENNETH N · 2010 to 2010
$500k
GPU Computing Cluster for Transformative Public Health driven Molecular ScienceS10OD034382 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DURKIN, KATHLEEN A · 2023 to 2023
$491k
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NCI NIH HHS R35 CA263814NCRR NIH HHS S10 RR027172NIH HHS S10 OD024998NIH HHS S10 OD034382
6 · The paper itself

Abstract

Vicinal difluorides adopt defined conformations due to the electronic properties of fluorine. Therefore, they could be valuable for controlling the constellation of functional groups about acyclic C-C bonds in organic molecules if all stereoisomers of the difluorides could be synthesized. However, stereoselective synthesis of vicinal difluorides has been cumbersome. The location of functional groups within organic molecules is important because it influences function, particularly biological function. We report a catalytic synthesis of acyclic vicinal difluoride stereoisomers by C-C bond formation between two monofluoro units, along with crystallographic and computational data showing that the

Indexed as

chemoproteomic profilingconformational controlstereodivergent synthesistransition metal catalysisvicinal difluoride

Identifiers

PMID41394327
PMCPMC12700069

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.