ArticleFrontiers in rehabilitation sciences2025
Perceived quality of life, fatigue and the metabolic cost of walking in generalized hypermobility spectrum disorder and hypermobile Ehlers-Danlos syndrome.
Article in Frontiers in rehabilitation sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
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Abstract
Introduction: Individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) often experience chronic pain, leg fatigue and/or pain, which may contribute to a higher metabolic cost of walking. How these subjective measures may manifest in an elevated metabolic cost of transport and perceived pain at varying walking speeds remains to be evaluated. Methods: We recruited 11 HSD/hEDS participants (33 ± 14 yrs, 170 ± 6. cm, weight 71 ± 11 kg) and 11 age- and sex-matched controls. Self-reported subjective outcome measures of health-related quality of life, fatigue severity, and foot function were evaluated prior to treadmill walking using the 36-Item Short Form Health Survey (SF-36) and the Fatigue Severity Scale (FSS). Participants also rated their self-perceived leg pain/fatigue following 3 x 6 min of treadmill walking at 80%, 100% and 120% of preferred walking speed (PWS). Cost of transport (CoT) was calculated from indirect calorimetry. Results: CoT was significantly higher in HSD/hEDS compared to CON at all speeds ( Discussion: These results have important implications for exercise prescription in individuals with HSD/hEDS whose CoT is higher during walking, which may exacerbate already elevated symptoms of pain and fatigue.
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