Evidence map›Paper›PMID 41394315›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2025

Characterisation of the function of a lncRNA containing SINE-VNTR-Alu 67 to regulate the genes at the

Kynen Piacentini, Alexander Fröhlich, Abigail Pfaff, Sulev Kõks

Abstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kynen PiacentiniPerron Institute for Neurological and Translational Science, Perth, WA, Australia.
Alexander FröhlichUK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Abigail PfaffPerron Institute for Neurological and Translational Science, Perth, WA, Australia.
Sulev KõksPerron Institute for Neurological and Translational Science, Perth, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disease that involves many interlinking pathways and genetic elements that remain to be fully understood and characterised. Non-coding genetic elements have long been overlooked, however recent advancements in the field have highlighted their importance with an area of interest being transposable elements. SINE-VNTR-Alu (SVA) elements are the youngest and smallest subset of retrotransposons that are only found within hominid species. SVAs have been shown to have strong regulatory impacts within our genome and can affect progression of neurodegenerative disease such as PD. Previous studies identified an SVA, polymorphic for its presence/absence, that was associated with changes in gene expression at the

Indexed as

Gene Expression RegulationRNA, Long NoncodingShort Interspersed Nucleotide Elementstau ProteinsCell Line, TumorHumansParkinson DiseaseMAPT protein, humanRNA, Long Noncodingtau Proteinsdifferential gene expressionLncRNAMAPT locusRT-qPCRSINE-VNTR-Alu 67

Identifiers

PMID41394315
PMCPMC12695722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.