Evidence map›Paper›PMID 41394308›Full record

ReviewNeuroprotection (Chichester, England)2025

The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke.

Weihong Du, Yuxian He, Liangchen Li, Xinchun Jin, Panpan Geng

Abstract readReview
In one paragraph

Review in Neuroprotection (Chichester, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. DPSCs-Exos promote OPCs differentiation and white matter repair via Myl9-mediated PRMT5 nucleation after ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  3. Review
  4. Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weihong DuDepartment of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China.
Yuxian HeDepartment of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China.
Liangchen LiDepartment of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China.
Xinchun JinDepartment of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China.ORCID https://orcid.org/0000-0002-5351-7914
Panpan GengDepartment of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke can cause motor sensory impairment and cognitive impairment. Current interventions focus on thrombolysis or thrombectomy in the acute stage, and promoting the recovery of neurological function during the chronic stage. However, so far, the effect on ischemic brain injury has been limited. Many patients do not receive timely and effective treatment, resulting in high rates of disability and mortality worldwide. In recent years, basic studies have shown that stem cells and their exosomes have a good effect on the protection of nerve function in ischemic brain injury, which has attracted the attention of researchers. This review describes the progress of the work on the stem cells and exosomes in ischemic stroke, in particular, the promising therapy of exosomes.

Indexed as

exosomesischemic strokestem cells

Identifiers

PMID41394308
PMCPMC12699548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.