Evidence map›Paper›PMID 41394306›Full record

ArticleNeuroprotection (Chichester, England)2025

Effects of senescence on astrocyte to brain endothelial cell signaling.

Shuzhen Guo, Gen Hamanaka, Fang Zhang, Janice Lee, Ji Hyun Park, Wenlu Li, Ken Arai, Eng H Lo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroprotection (Chichester, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuzhen GuoNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.ORCID https://orcid.org/0000-0003-0627-5278
Gen HamanakaNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.
Fang ZhangNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.
Janice LeeNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.
Ji Hyun ParkNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.
Wenlu LiNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.
Ken AraiNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.
Eng H LoNeuroprotection Research Laboratory, Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical School Charlestown MA USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aging affects almost all aspects of central nervous system (CNS) function, including the blood-brain barrier (BBB). Here, we use cell culture models to ask whether senescence, a cellular feature of aging, alters the BBB by modifying interactions between astrocytes and brain endothelial cells. Methods: Human astrocyte and Human brain microvascular endothelial cells were subcultured and maintained for cells at low and high passages, then confirmed with senescence-associated β-galactosidase staining and gene expression of cyclin-dependent kinase inhibitor 2A ( Results: Young astrocytes (cumulative population doublings [CPD] ≤ 4) modified the expression of barrier genes and decreased brain endothelial permeability in coculture, whereas aged senescent astrocytes (CPD ≥ 9) had no effects (45.5% ± 18.0% vs. 122.8% ± 28.6%, Conclusion: Taken together, these findings suggest that increased angiotensin signaling from astrocytes to brain endothelium may partly mediate the decrease of BBB function in the aging CNS.

Indexed as

agingangiotensinastrocyteblood–brain barrierendothelialsenescence

Identifiers

PMID41394306
PMCPMC12699544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.