ArticleClinical ophthalmology (Auckland, N.Z.)2025
Investigation of Age-Related Changes in Iris Curvature Among Japanese Participants.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Angle-closure glaucoma is more common among Asians, including Japanese individuals, and iris curvature (I-Curv) is reportedly useful for its diagnosis. To investigate age-related changes in iris configuration and their associated factors in Japanese participants using I-Curv measured using anterior segment optical coherence tomography (AS-OCT). Patients and Methods: A total of 480 healthy Japanese individuals aged 20-99 years were enrolled. The anterior segment parameters of the anterior chamber, angle, and iris were measured using AS-OCT (CASIA2). The relationships between I-Curv and other parameters were assessed using Spearman's rank correlation coefficient. Differences in the I-Curv among age groups were analyzed using the Kruskal-Wallis test, followed by pairwise comparisons with Bonferroni correction. Multiple regression analysis was performed with I-Curv as the dependent variable and age, refractive error, sex, axial length, and anterior segment parameters as the independent variables. Further, eyes were classified into concave and convex groups based on the sign of I-Curv, and clinical characteristics were compared between these groups. Results: I-Curv tended to increase (become more anteriorly convex) with age, showing significant differences among age groups (P < 0.001). However, no significant differences were observed between the adjacent age groups. Spearman correlation revealed significant negative correlations between I-Curv and angle/anterior chamber parameters such as AOD500 and ACD, and positive correlations with LV, age, and refractive error. Multiple regression analysis identified AOD500, ARA500, LV, refractive error, age, and pupil diameter as significant factors influencing the I-Curv (R² = 0.824, P = 0.043). Compared with the convex group, the concave group was significantly younger, had greater myopia, wider anterior chambers and angles, and tended to include more males (P < 0.05). Conclusion: The iris tended to become more anteriorly convex with increasing age, and these changes appeared to be strongly influenced by angle configuration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.