Evidence map›Paper›PMID 41394255›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

Sorsby Fundus Dystrophy in an Asian Pedigree: Pathogenic Timp3 P.Y191c Variant Impairs Its Binding with Mmp2/9 and Cellular Localization.

Miao Li, Haiying Peng, Shenao Ding, Yuanmeng Wei, Leying Zhang, Zhongqiang Zhou, He Tang, Pingling Shi, Yingjuan Liang, Guanfeng Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miao LiHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Haiying PengHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Shenao DingHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Yuanmeng WeiHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Leying ZhangHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Zhongqiang ZhouHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
He TangHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Pingling ShiHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Yingjuan LiangHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Guanfeng LiDepartment of Ophthalmology, Henan Children's Hospital, Zhengzhou, People's Republic of China.
Ye TaoHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.
Zongming SongHenan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan, People's Hospital, Zhengzhou, People's Republic of China.ORCID 0009-0007-2322-2940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To characterize the clinical phenotype and elucidate the pathogenic mechanism of the novel Methods: Affected family members underwent comprehensive ophthalmic evaluations. Genetic analysis was performed via whole-exome and Sanger sequencing. An ARPE-19 cell models overexpressing wild-type or mutant Results: A heterozygous Conclusion: The novel

Indexed as

MMP2MMP9pathogenic variantsorsby fundus dystrophyTIMP3

Identifiers

PMID41394255
PMCPMC12701730

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.