ReviewCureus2025
Vitamin D Deficiency and Clinical Outcomes in Adult Burn Patients: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency is highly prevalent among burn patients and may impair immune function, inflammation control, and wound healing. To clarify its clinical impact, we conducted a systematic review and meta-analysis of observational studies evaluating outcomes stratified by baseline vitamin D status in adult burn patients. Six endpoints were analyzed: wound infection or cellulitis, bacteremia or septicemia, intensive care unit (ICU) admission, mechanical ventilation, ICU length of stay (LOS), and total hospital LOS. Random-effects models generated pooled odds ratios (ORs) and weighted mean differences (WMDs) with 95% CI. Five studies comprising 1,814 patients met the inclusion criteria. Vitamin D sufficiency was associated with significantly reduced odds of bacteremia or septicemia (OR 0.21; 95% CI 0.10-0.43; p<0.0001) and shorter ICU (WMD -5.5 days; p=0.04) and hospital LOS (WMD -5.7 days; p=0.003). A borderline reduction in mechanical ventilation was also observed (OR 0.55; p=0.05), whereas ICU admission and wound infection outcomes showed non-significant trends favoring sufficiency. Heterogeneity varied across outcomes, with the bacteremia analysis demonstrating no heterogeneity (I²=0%). Vitamin D deficiency appears associated with increased systemic infection risk and prolonged hospitalization following burn injury, supporting further prospective trials to evaluate vitamin D supplementation in burn care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.