SynthesisFrontiers in pharmacology2025
Efficacy and safety of the commercial Chinese polyherbal preparation
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Purpose: This study aims to systematically evaluate the efficacy and safety of LSW as adjunctive treatment in treating HZ/PHN. Methods: A comprehensive search was conducted across PubMed, Web of Science, Embase, Cochrane Library, ClinicalTrials.gov, and four Chinese databases. Eligibility criteria (PICOS) included the following: (1) patients with HZ/PHN; (2) LSW as adjunctive therapy (experimental group); (3) conventional treatment only (control group); (4) primary outcomes: vesicle cessation, scab formation, VAS, and PHN incidence; secondary outcomes: scab shedding time, time to pain resolution, duration of pain persistence, PHN efficacy, and adverse reactions; and (5) RCTs. Risk of bias was assessed using ROB 2.0, and data synthesis/analysis used RevMan 5.4. No restrictions on language. Results: A total of 21 RCTs (n = 1,478) were included. Meta-analysis demonstrated that LSW plus conventional treatment significantly outperformed conventional treatment alone in shortening vesicle cessation time [MD = -1.44, 95% CI (-1.66, -0.93), Conclusion: Adjunctive LSW therapy demonstrates potential to shorten herpes lesion healing time, improve treatment outcomes, and effectively prevent postherpetic neuralgia compared to conventional treatment alone. It also significantly reduces both the duration of pain and the overall disease course. Nevertheless, limitations in the current evidence base, including study quality and quantity, necessitate further rigorous investigation to confirm the long-term efficacy and safety profile of this combined intervention. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/, identifier CRD42024595203.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.