Evidence map›Paper›PMID 41394013›Full record

SynthesisFrontiers in reproductive health2025

Systematic review of challenges and prospective recommendations of medically assisted reproductive technology in developing countries.

Melese Dereje Mesfin, Dahabo Adi Galgallo, Leman Atmaca, Kálmán András Kovács, Ákos Várnagy, Viktória Prémusz

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melese Dereje MesfinDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Dahabo Adi GalgalloDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Leman AtmacaDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Kálmán András KovácsNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Ákos VárnagyNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Viktória PrémuszDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Infertility is a global public health issue which affects significant portion of adult population. In developing nations, infertility has long been disregarded as a reproductive health problem. Despite being available for almost for five decades, most people in resource-poor nations still face challenges to access assisted reproductive technology. We conducted this systematic review to explore the reasons behind such gaps and solutions outlined to address them. Methods: After a study protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), we conducted a comprehensive search using predefined keywords and medical subject headings across major electronic databases: - Ovid MEDLINE, PubMed, Web of Science, and Google Scholar. Results and Discussion: The database search resulted in total of 3097 citations; after removal of 2256 duplicates, 765 citations were selected for title and abstract review. A full text review was conducted on the 137 articles 43 studies were included in the final analysis. The majorly cited challenge was the high costs associated with treatment, followed by accessibility and infrastructural obstacles, psychosocial and cultural barriers including the unacceptance of a baby born from assisted reproduction. Absence of supportive policies coupled with religious factors worsen the problem. Governmental, non-governmental, and international organizations should collaborate to address affordability and accessibility issues and to resolve socio-cultural and religious challenges through the inclusion of infertility treatment in the existing health system, revisiting the financial mechanisms, and creating supportive policies in partnership with community and religious leaders. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025632094, PROSPERO CRD42025632094.

Indexed as

assisted reproductive technologies (ART)barrierschallengesdeveloping countriesintracytoplasmic sperm injectionin vitro fertilizationrecommendation

Identifiers

PMID41394013
PMCPMC12695750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.