ArticleFrontiers in reproductive health2025
Integrating salpingoscopy and immunohistochemistry to improve tubal infertility diagnosis: a retrospective cohort study.
Article in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- HFTMSCs alleviate uterine fibrosis and restore fertility in intrauterine adhesion models.Reproductive biology and endocrinology : RB&E · 2026Article
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Abstract
Introduction: Tubal factor infertility is one of the most prevalent and diagnostically complex causes of female infertility. Standard imaging modalities, including hysterosalpingography and laparoscopy, frequently fail to detect subtle mucosal or molecular abnormalities. This study investigated whether combining salpingoscopy with immunohistochemical (IHC) profiling improves diagnostic precision and prognostic assessment in women with tubal-factor infertility. Methods: This retrospective observational cohort study included 197 women who underwent laparoscopy between April 2020 and February 2025. Salpingoscopy was used to grade mucosal pathology severity, and ampullary biopsies were analyzed by IHC for CD138, Ki-67, and estrogen/progesterone receptors. A composite prognosis score incorporated clinical history, duration of conservative therapy, salpingoscopic findings, and IHC results. Spearman's rank correlation assessed associations between diagnostic parameters and pregnancy outcomes (natural or assisted). Results: Higher salpingoscopic severity scores were significantly associated with reduced pregnancy likelihood ( Discussion: Integrating salpingoscopic visualization with IHC profiling enhances detection of subtle mucosal and molecular abnormalities that are frequently missed by conventional diagnostic approaches. This combined modality offers superior prognostic accuracy and may guide personalized surgical and assisted reproductive treatment strategies. Ethical approval was obtained from the Ethics Committee of the Kazakhstan Medical University «KSPH» (IRB-64-2023).
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