ArticleInternational journal of clinical and experimental pathology2025
Splenic megakaryocyte density in immune thrombocytopenia: insights from a histologic analysis of splenectomy specimens.
Article in International journal of clinical and experimental pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesImmune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet destruction, for which multiple pathogenic mechanisms have been proposed. However, the spleen, as the principal site of platelet clearance, plays a pivotal role in its pathogenesis. The objective of this study was to evaluate the histopathologic features of splenectomy specimens in patients with ITP, with a particular emphasis on the presence of megakaryocytes (MKCs) in the spleen and their relationship with clinical factors.
methodsWe examined spleen specimens from 16 patients with ITP and 10 controls, analyzing several aspects, including MKC density, white pulp (WP) histology, and immune cell markers.
resultsThere was a higher MKC density in the spleens of patients with ITP in comparison to control spleens (
conclusionsThese findings suggest that elevated MKC density in the spleens of patients with ITP may reflect distinct pathophysiologic pathways, possibly involving B cell-independent mechanisms. MKC density may serve as a simple and practical histologic marker for evaluating disease severity in patients with ITP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.