ArticleFrontiers in nutrition2025
Association between prognostic nutritional index and prognosis in acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: a retrospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Blood urea nitrogen-to-albumin ratio predicts mortality in acute graft-versus- host disease after allogeneic stem cell transplantation.Frontiers in immunology · 2026Article
- Association between the prognostic nutritional index and early mortality of AML patients after allogeneic HSCT: a retrospective cohort analysis.Frontiers in oncology · 2026Article
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6 authors.
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Abstract
Background: Evidence on the association between prognostic nutritional index (PNI) and prognosis in acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited. Objective: This study aims to investigate the relationship between PNI levels and prognosis in patients experiencing aGVHD following allo-HSCT. Methods: We conducted a retrospective cohort study of patients who underwent allo-HSCT at Henan Cancer Hospital from January 2019 to December 2024. Eligible patients were those diagnosed with aGVHD following allo-HSCT. Data on PNI levels, clinical outcomes, and demographics were extracted from medical records. The primary outcomes were overall survival (OS) and event-free survival (EFS). Multivariable Cox regression and subgroup analyses were performed to assess the relationship between PNI levels and prognosis, adjusting for confounders. Results: This study included 109 eligible patients with a mean age of 29.4 ± 15.3 years. Over a 30-month follow-up, there were 69 deaths, 3 relapses/progressions, and 37 survivors. Among the participants, 51 had Grade I-II aGVHD, and 58 had Grade III-IV aGVHD. After adjusting for confounders, the adjusted hazard ratios (HR) for PNI and OS in T2 (35.8-42.5) and T3 (42.5-59.7) were 0.52 (95% CI: 0.23-0.86, Conclusion: Our study underscores the association between lower PNI levels and poorer prognosis in aGVHD patients following allo-HSCT, emphasizing the need for further research to validate PNI as a reliable prognostic biomarker.
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