Evidence map›Paper›PMID 41393946›Full record

ArticleFrontiers in nutrition2025

The interaction between the gene SOD1 rs2070424 and the plasma zinc/copper ratio predicts renal function impairment.

Jingsi Chen, Jiaju Ge, Jiayuan Song, Tianci Wang, Yuqin Ma, Xiaoyan Qian, Chang Zhou, Qiuguo Wang, Senlin Zhu, Xiyu Wu and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Jingsi Chen *Department of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Jiaju Ge *Department of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Jiayuan SongDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Tianci WangDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Yuqin MaSuzhou Industrial Park Centers for Disease Control and Prevention, Suzhou, China.
Xiaoyan QianSuzhou Industrial Park Centers for Disease Control and Prevention, Suzhou, China.
Chang ZhouDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Qiuguo WangDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Senlin ZhuDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Xiyu WuDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Hongzhen DuDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Liqiang QinDepartment of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, Suzhou, China.
Zengning LiDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Essential trace elements zinc and copper have been suggested to play a role in renal function. However, the balance between these elements and their interaction with genetic variation in Methods: We conducted a prospective study involving 1,274 middle-aged and elderly participants from the "135" cohort in 2015. Cox regression analyses were used to assess associations between plasma trace elements, Results: After adjusting for multiple variables, the hazard ratios (HRs) (95% CI) comparing the highest to the lowest tertiles were 1.303 (1.037, 1.637) for zinc, 1.615 (1.275, 2.046) for the zinc/copper ratio, and 0.709 (0.558, 0.900) for copper. Compared with the GG genotype, the AG and AA genotypes were positively associated impaired renal function (HR: 1.282, 95% CI: 1.003, 1.639). Positive associations between impaired renal function and plasma zinc ( Conclusion: Decline in renal function was positively correlated with plasma zinc and the zinc/copper ratio and negatively correlated with plasma copper. The relationship between impaired renal function and both zinc and the zinc/copper ratio was modified by rs2070424 genotypes. Taken together, considering zinc/copper ratio provides a more informative summary than single-metal measures and shows partial incremental discrimination.

Indexed as

copperrenal functionsuperoxide dismutase 1zinczinc/copper ratio

Identifiers

PMID41393946
PMCPMC12695532

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