ArticleAIDS research and treatment2025
BIKSWITCH Study: Effectiveness and Safety of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) From Therapies Not Based on Integrase Inhibitors in Virologically Suppressed HIV-Infected Patients.
Article in AIDS research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effectiveness and Safety Profile of BIC/TAF/FTC in People living with HIV Switched from Other Antiretroviral Regimens: A Real-Life Retrospective Cohort Analysis.Le infezioni in medicina · 2026Article
- BIKSWITCH Study: Effectiveness and Safety of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) From Therapies Not Based on Integrase Inhibitors in Virologically Suppressed HIV-Infected Patients.AIDS research and treatment · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Beyond initial antiretroviral therapy (ART), bictegravir/emtricitabine/tenofovir alafenamide 50/200/25 mg (B/F/TAF) has been evaluated as an option for the continuation of treatment for virologically suppressed individuals who switch from other regimens. While treatment-emergent resistance to bictegravir has not been observed in clinical trials, rare case reports have described resistance development during B/F/TAF therapy, typically in the context of suboptimal adherence. Its favourable safety profile, minimal drug-drug interactions and proven virological efficacy suggest that virologically suppressed individuals may benefit from switching to B/F/TAF. Methods: Descriptive, retrospective, observational study of adults with HIV infection receiving effective non-INSTI (integrase strand transfer inhibitors)-based ART who switched to a B/F/TAF, but not all were suppressed. We compared individuals' viral loads, CD4+ lymphocyte counts, glomerular filtration rates, and lipid profiles before the switch and after 24 weeks of B/F/TAF. Safety was also assessed. Results: Seventy-nine individuals switched from non-INSTI-based therapies to B/F/TAF. At 24 weeks after the switch, HIV-1 RNA < 50 copies/mL was reported in 96.1% and 92.4% of participants per protocol and intention-to-treat analysis, respectively, compared to 81.0% at baseline. This represents a 15.1% increase in virologic suppression (viral load < 50 copies/mL) compared to baseline. No significant changes were detected in the CD4+ lymphocyte count, glomerular filtration rate, or lipid profile. Adverse events (AEs) were reported in 5.1% of patients. Three patients discontinued treatment due to AEs. Conclusions: The results of this study suggest that patients can switch to B/F/TAF from non-INSTI-based therapies without compromising the effectiveness or safety of ART.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.