Evidence map›Paper›PMID 41393901›Full record

ArticleGut microbes reports2025

Myeloperoxidase gene knockout causes local inflammation and dysbiosis in the murine gut.

Jack J Wang, Yawen Hu, Scott Jennings, Meng Luo, Christopher M Taylor, William M Nauseef, Guoshun Wang

Abstract read
In one paragraph

Article in Gut microbes reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jack J WangDepartment of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Yawen HuDepartment of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Scott JenningsDepartment of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Meng LuoDepartment of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Christopher M TaylorDepartment of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
William M NauseefInflammation Program, Roy J. and Lucille Carver College of Medicine, University of Iowa, and Veterans Administration Medical Center, Iowa City, IA, USA.
Guoshun WangDepartment of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.ORCID 0000-0002-4057-1399

Funding

Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI Arunava Roy · 2017 to 2026
$22.4M
Innate Immune Defect and Neutrophilic Inflammation in Cystic FibrosisR01HL150370 · NHLBI · LSU HEALTH SCIENCES CENTER · PI WANG, GUOSHUN · 2020 to 2023
$1.5M
Development of a Rabbit Model for Myeloperoxidase DeficiencyR21AI185243 · NIAID · LSU HEALTH SCIENCES CENTER · PI WANG, GUOSHUN · 2024 to 2025
$413k
NHLBI NIH HHS R01 HL150370NIAID NIH HHS R21 AI185243NIGMS NIH HHS P20 GM121288
6 · The paper itself

Abstract

Myeloperoxidase (MPO), predominantly expressed in neutrophils, catalyzes the production of hypochlorous acid (HOCl) that plays an integral role in the host defense against invading pathogens. However, little is known about its role in maintaining normal gut microbiome and function. Here, we report the comparisons of inflammation and microbiome in the intestines of WT and MPO

Indexed as

bowel movementepithelial integritygut microbiotaintestinal inflammationMyeloperoxidase

Identifiers

PMID41393901
PMCPMC12700598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.