ArticleOrthopaedic journal of sports medicine2025
Tendon-Bone Interface Healing Improvement by Moderate Treadmill Exercise After Anterior Cruciate Ligament Reconstruction in a Murine Model.
Article in Orthopaedic journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The effect of preoperative rehabilitation exercises on postoperative bone mineral density, tendon-bone healing, and physical function after anterior cruciate ligament reconstruction: a multi-center randomized controlled clinical trial.BMC sports science, medicine & rehabilitation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent studies have used the anterior cruciate ligament reconstruction (ACLR) mouse model to study the tendon-bone healing process. Although mechanical load has an important effect on ACL graft healing, only a limited number of studies have investigated the effect of treadmill exercise. Purpose/Hypothesis: This study aimed to investigate the effects of different mechanical loading stimuli on the tendon-bone interface (TBI) healing process after ACLR in mice. It was hypothesized that moderate loading would positively affect TBI healing after ACLR. Study Design: Controlled laboratory study. Methods: A total of 58 C57BL/6 male mice (12 weeks old) underwent ACLR of the right knee. The first 30 mice were assigned to 5 exercise groups (n = 6 per group) to evaluate the different exercise regimens (study arm 1). After the optimal exercise regimen was identified, an additional 28 mice were included, and 14 mice in the exercise regimen were compared with 14 free cage controls (study arm 2). Starting 7 days after surgery, treadmill exercise was performed 5 days per week for 3 weeks. All animals were euthanized 4 weeks after surgery. Microfocus computed tomography (μCT) imaging, biomechanical testing, and histological tendon-bone tunnel healing (TBTH) scoring were performed. Statistical analyses were performed using the Wilcoxon signed rank test, the Mann-Whitney Results: In study arm 1, no significant intergroup differences were observed in the μCT analysis ( Conclusion: Our study demonstrated that moderate treadmill exercise after ACLR positively affects TBI healing in the femoral and tibial tunnels in the murine model. Future studies are necessary to objectively quantify the optimal type, magnitude, and duration of loading. Clinical Relevance: There may be a role for a moderate-load rehabilitation protocol to improve healing of the tendon graft-bone interface in patients after ACLR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.