ArticleCureus2025
Early Cognitive Outcomes After Carotid Endarterectomy in Asymptomatic Stenosis: A Pilot Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06391866 (Assessing Neuroinflammation and Oxidative Stress After Cardiac Surgery), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Neuroinflammation and Oxidative Stress After Cardiac Surgery: Unveiling Molecular Dynamics and Clinical Outcomes
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Perioperative neurocognitive disorders (PNDs) are important determinants of postoperative quality of life. Evidence on early cognitive outcomes after carotid endarterectomy (CEA) in neurologically intact, asymptomatic patients remains limited, and reported incidences vary widely. Methodology This single-center prospective observational pilot study (ClinicalTrials.gov NCT06391866) enrolled 18 statin-treated adults (mean age 78.3 ± 4.9 years) with asymptomatic ≥70% ICA stenosis undergoing CEA under balanced general anesthesia with bilateral near-infrared spectroscopy (NIRS) and entropy monitoring. Neurological (National Institutes of Health Stroke Scale (NIHSS)) and Montreal Cognitive Assessment (MoCA) tests were done preoperatively and 24 hours postoperatively; patients with delirium were excluded. Subjective cognitive change was assessed at 30 days by interview. Early POCD was a ≥2-point MoCA decline. Results Mean clamp time was 29.1 ± 6.4 minutes; no shunts were used. NIRS showed no ≥25% decrease or >10% increase from baseline after unclamping. NIHSS was unchanged (median 1 → 1, p > 0.05). MoCA fell non-significantly from 30.0 ± 1.8 to 29.6 ± 2.3 (p > 0.05); one patient (5.6%) met criteria for early POCD. At 30 days, one patient reported improvement, 13 had no change, three were lost to follow-up, and one died of non-neurological causes. No strokes, transient ischemic attacks (TIAs), or hyperperfusion occurred. Conclusions In this small pilot study of neurologically intact, asymptomatic patients undergoing CEA with meticulous monitoring, early postoperative cognitive decline was rare, neurological function remained stable, and no major perioperative complications occurred. These findings suggest that with careful intraoperative management, CEA is generally safe regarding early cognitive outcomes in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.