ArticleCureus2025
Erythrocyte Glutathione/Redox Balance and Serum Thiol/Disulfide Homeostasis in Hepatitis B and Hepatocellular Carcinoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Glutamate dehydrogenase activity and non-ınvasive fibrosis ındices (APRI, AAR, FIB-4) compared to FibroScan in chronic hepatitis B and hepatocellular carcinoma.Irish journal of medical science · 2026Article
- iNOS/NOX-mediated stress, telomerase activity, and hTERT expression as potential biomarkers in sleep apnea.Irish journal of medical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Oxidative stress and imbalance in thiol-disulfide homeostasis play a crucial role in the pathogenesis and progression of liver-related diseases. This study aimed to determine the thiol-based redox system and glutathione homeostasis by evaluating erythrocyte glutathione (GSH), superoxide dismutase (SOD), total antioxidant status (TAS), total oxidant status (TOS), and malondialdehyde (MDA) levels and serum thiol/disulfide and GSH parameters in patients with hepatitis B virus (HBV) and hepatocellular carcinoma (HCC). Methodology The study included 60 HBV and 22 HCC patients and 40 healthy subjects. SOD, TAS, TOS, oxidative stress index (OSI), MDA, GSH, total thiol, native thiol, and disulfide levels were measured to determine serum and erythrocyte oxidant/antioxidant balance. The relationship between these biomarkers and liver function tests was evaluated. Results In the serum of HBV and HCC patients, significant increases were observed in MDA, TOS, and OSI levels. In contrast, significant decreases were noted in GSH, SOD, TAS, total thiol, and native thiol levels. Oxidant-antioxidant parameters in erythrocytes paralleled those in serum. In HBV patients, alanine aminotransferase and lactate dehydrogenase levels were negatively correlated with TOS and OSI. In addition, a positive correlation was found between hepatitis B surface antigen levels and total thiol and native thiol levels. MDA, SOD, and total thiol levels showed high diagnostic performance in the diagnosis of HCC with area under the curve values of 0.993, 0.800, and 0.815, respectively. Conclusions Measurement of serum thiol-disulfide balance and erythrocyte SOD, MDA, and TOS levels may be helpful in the diagnosis of HBV and HCC. Antioxidant support that increases GSH and thiol levels is a critical approach to prevent disease progression.
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Registered trials
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