ArticleCureus2025
Pulmonary Metastasectomy Versus Stereotactic Beam Radiation Therapy for Sarcoma Pulmonary Metastasis: A Retrospective Cohort Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [When and how are pulmonary metastases surgically treated in sarcomas?]Chirurgie (Heidelberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Sarcomas are a diverse group of malignancies that most commonly metastasize to the lungs. Surgical metastasectomy has been considered the gold standard for oligometastatic disease that is technically resectable in medically appropriate patients, while stereotactic body radiotherapy (SBRT) offers a non-surgical alternative that has been shown to be safe and effective. The current literature remains limited in direct comparisons between these treatments. Methodology A retrospective cohort study was performed at a single academic center between 2005 and 2024 that included 99 patients with metastatic sarcoma to the lungs. Patients received metastasectomy only (n = 34), SBRT only (n = 28), or both modalities (n = 37). The primary endpoint was overall survival from metastatic diagnosis. Secondary endpoints included treatment-related complications. Multivariable Cox proportional hazards modeling adjusted for treatment modality, age, number of nodules, chemotherapy use, and other prognostic factors. Results Before controlling for confounding, metastasectomy was associated with the greatest median survival at 45.5 months, followed by both at 37.5 months and SBRT at 24.5 months. On multivariable analysis, metastasectomy was associated with significantly reduced mortality (hazard ratio (HR) = 0.40, 95% confidence interval (CI) = 0.20-0.82, p = 0.012). SBRT may reduce the risk of mortality, but significance was not reached (HR = 0.86, p = 0.648). Age >70 years (HR = 2.39, p = 0.015) and ≥3 nodules (HR = 2.27, p = 0.008) predicted worse survival. Wide resection of metastases, including microscopic margins, was not associated with statistically significantly reduced mortality when compared to non-wide metastasectomy, with residual microscopic disease (HR = 0.693, p = 0.328). Complication rates were similar between SBRT (17.2%) and metastasectomy (13.4%). Conclusions Metastasectomy should remain the preferred, first-line treatment for oligometastatic sarcoma to the lungs in appropriately indicated patients. SBRT remains a safe and effective alternative for patients with unresectable disease or those who are medically inoperable.
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