ArticleCureus2025
Absence of Modulation in Interhemispheric Inhibition During Sustained Muscle Contraction as Measured by Ipsilateral Silent Period.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundInterhemispheric inhibition (IHI) can be assessed using transcranial magnetic stimulation (TMS). The ipsilateral silent period (ISP), which represents IHI from the primary motor areas (M1) on the TMS stimulation side to the M1 on the opposite side of the TMS stimulation, is elicited. The variability in ISP associated with changes in contraction intensity at 30% and 50% of maximum voluntary contraction (MVC) and the muscle of the contralateral limb remains unclear. MATERIALS AND
methodsThis study investigated the influence of these variables on ISPs. We performed electromyography monitoring for ISP and evaluated motor evoked potentials (MEPs) and contraction force during motor tasks in 15 right-handed healthy adults. Measurements involved the bilateral first dorsal interosseous and the right biceps brachii muscles. After identifying the optimal TMS target (hot spot) and establishing the resting motor threshold, 20 TMS pulses were applied in each condition.
resultsThere was no interaction or main effect on ISP duration under any condition, while MEP displayed significant interaction and main effects for contraction intensity and muscle type. We found no variations in ISP across motor tasks in this study.
conclusionsWe observed no ISP alterations despite changes in M1 excitability, suggesting that other brain regions, such as the supplementary motor area (SMA), may modulate IHI.
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