Role of the Medial Agranular Cortex in Sensory-Motor Integration During Walking: Insights From a Rodent Stroke Model.

Daisuke Ishii, Hironobu Osaki, Arito Yozu, Tatsuya Yamamoto, Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno

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Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Daisuke IshiiDepartment of Cognitive and Behavioral Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JPN.

Hironobu OsakiLaboratory of Functional Brain Circuit Construction, Graduate School of Brain Science, Doshisha University, Kyoto, JPN.

Arito YozuDepartment of Rehabilitation Medicine, Nippon Medical School, Tokyo, JPN.

Tatsuya YamamotoFaculty of Medical and Health Sciences, Tsukuba International University, Ibaraki, JPN.

Satoshi YamamotoDepartment of Physical Therapy, Ibaraki Prefectural University of Health Sciences, Ibaraki, JPN.

Mariko MiyataDivision of Neurophysiology, Department of Physiology, School of Medicine, Tokyo Women's Medical University, Tokyo, JPN.

Yutaka KohnoCenter for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the rodent motor cortex, limb movements are primarily governed by the lateral agranular cortex (AGl), whereas the medial agranular cortex (AGm) has been proposed to contribute to higher-order aspects of motor control. However, its independent contribution to sensory-motor integration has not been established. Previous studies have shown that infarcts encompassing both the AGl and AGm cause contralateral motor impairments, suggesting, but not proving, that the AGm might participate in movement control. In this study, we specifically tested whether focal lesions restricted to the AGm impair skilled locomotion. Using the ladder rung walking task, which requires precise paw placement based primarily on somatosensory cues with additional visual contributions, we examined mice with focal photothrombotic infarcts centered within the AGm at +2.0, +1.5, +1.0, or +0.5 mm anterior to bregma. To enable objective assessment, we developed an automated analysis pipeline using DeepLabCut

Indexed as

forelimbhindlimbmotor cortexstrokewalking

Identifiers

PMID41393722

DOI10.7759/cureus.96737

PMCPMC12701541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.