ArticleCureus2025
MRI-Based Medial Temporal Atrophy May Reflect Amyloid PET Positivity in Cognitively Normal Individuals: A Preliminary Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Clinical and MRI features associated with amyloid positivity in secondary screening for anti-amyloid-β therapy.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated whether magnetic resonance imaging (MRI)-based medial temporal morphometry can predict amyloid positron emission tomography (PET) positivity in cognitively normal individuals. Sixteen consecutive participants (eight amyloid PET-positive and eight PET-negative) were retrospectively identified, all within the normal cognitive range (Mini-Mental State Examination 28-30). Amyloid PET was performed using florbetapir, with visual interpretation as the primary diagnostic criterion and Centiloid values as supportive measures. MRI-derived volumetric analysis was conducted using the voxel-based specific regional analysis system for Alzheimer's disease (AD) to quantify medial temporal atrophy. Although between-group differences in hippocampal indices did not reach statistical significance, the PET-positive group showed a trend toward greater atrophy, and centiloid values correlated positively with medial temporal indices. Receiver operating characteristic analysis indicated fair discrimination, highest for the volume-of-interest-to-gray-matter ratio (area under the curve = 0.83). These preliminary findings suggest that subtle hippocampal alterations on routine structural MRI may mirror early amyloid pathology even before cognitive impairment, supporting the potential of MRI-based morphometric assessment as an adjunctive biomarker for early AD detection.
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Registered trials
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