Evidence map›Paper›PMID 41393625›Full record

ArticleCureus2025

Corneal Amiodarone Deposition and Its Implications for Autologous Serum Eye Drop Therapy: A Case Report.

Khushi Saigal, Shawn Sussmane, Sonal Tuli

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Khushi SaigalOphthalmology, University of Florida, Gainesville, USA.
Shawn SussmaneOphthalmology, University of Florida, Gainesville, USA.
Sonal TuliOphthalmology, University of Florida, Gainesville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal toxicity and deposits can develop from a variety of systemic and topical medications used in ophthalmic and non-ophthalmic care. We report a case of a 69-year-old man with dry eye syndrome on long-term amiodarone therapy who developed bilateral corneal verticillata shortly after initiating autologous serum eye drops (ASEDs). Despite improvement in epithelial healing, the new deposits raised concern for exacerbation of amiodarone-related corneal toxicity, possibly influenced by ASEDs. This case underscores the potential interaction between systemic therapy and ASEDs, highlighting the importance of careful monitoring in patients with ocular surface disease receiving medications known to cause ocular complications.

Indexed as

amiodarone keratopathyautologous serum eye dropscorneal drug depositiondry-eye diseaseocular surface toxicity

Identifiers

PMID41393625
PMCPMC12700184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.