ArticleCureus2025
A Clinical Case of Anti-synthetase Syndrome: Polysymptomatic and Underdiagnosed.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Antisynthetase syndrome (ASSD) encompasses a group of autoimmune diseases associated with the formation of antibodies against aminoacyl-tRNA synthetases (ARS). The medical literature describes a constellation of symptoms, including myositis, arthritis, Raynaud's phenomenon, interstitial lung disease (ILD), fever, skin rash, or "mechanic's hands." We present a case of a 51-year-old man admitted with SAS with a consumptive clinical picture, rhabdomyolysis, ILD, and myositis. Positive anti-PL-7 and anti-nuclear antibodies (ANA) were detected. After diagnostic confirmation, the patient was treated with high doses of methylprednisolone and subsequently with cyclophosphamide, with a good response to immunosuppressive therapy. This clinical case is of great importance given the rarity of the pathology and the diagnostic difficulty of a disease with such a wide range of clinical manifestations.
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