ArticleCureus2025
Effect of Dimethylaminohexadecyl Methacrylate With and Without Nystatin on the Hardness, Water Sorption, and Water Solubility of Polymethyl Methacrylate (PMMA) Denture Base Resin.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposePolymethyl methacrylate (PMMA) denture base resins provide a surface conducive to microbial colonization and biofilm formation, which can precipitate denture-related stomatitis. Incorporation of antimicrobial agents, such as dimethyl amino-ethyl hexadecyl dimethacrylate (DMAHDM) and nystatin, reduces this risk; however, their inclusion could alter the physicomechanical properties of PMMA. This study aimed to evaluate the effects of incorporating DMAHDM, alone or with nystatin, into PMMA denture base resin on Vickers microhardness, water sorption, and solubility. METHODOLOGY: Heat-polymerized PMMA specimens were prepared as control (A) and experimental groups with 5%, 10%, or 20% DMAHDM (B1-B3) with/without 500,000 IU nystatin (C1-C3). Hardness (n = 10/group) was tested using a calibrated Vickers indenter (300 g, 10 seconds). Water sorption (n = 5) and solubility (n = 5) were measured at 1 and 30 days and are reported in micrograms per square millimeter according to ISO 20795‑1. Between‑group comparisons used one‑way analysis of variance with Tukey's post hoc test (p < 0.05).
resultsAll DMAHDM‑containing groups exhibited higher hardness than the control (p < 0.001); 5% DMAHDM (B1) was significantly higher than other experimental groups (p < 0.001). Sorption and solubility increased with the concentration of DMAHDM and with the addition of nystatin. Converted per‑area values remained within ISO 20795‑1 limits across groups.
conclusionLow levels of DMAHDM significantly improve hardness, but higher concentrations and the addition of nystatin increase water uptake and solubility, which may negatively impact long-term stability. Optimization of DMAHDM loading is warranted.
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