Evidence map›Paper›PMID 41393436›Full record

ArticleBioinformation2025

Rage gene -374T/A polymorphism in South Indian diabetic nephropathy.

Ramesh Babu Murikipudi, Lakshmiprabha S, Pravallika P, Ponnudhali D, Rangabashyam S R, Rangarajan R

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Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ramesh Babu MurikipudiDepartment of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, Vinayaka Misson's Research Foundation (DU), Salem, Tamilnadu, India.
Lakshmiprabha SDepartment of Biochemistry, KMMC Medical College and Hospital, Muttom, Kanyakumari., St. Joseph University, Bengaluru, India.
Pravallika PDepartment of Physiology, Shridevi institute of medical sciences and research hospital Tumkur, Karnataka, India.
Ponnudhali DDepartment of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, Vinayaka Misson's Research Foundation (DU), Salem, Tamilnadu, India.
Rangabashyam S RDepartment of General medicine, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, India.
Rangarajan RDepartment of Biochemistry, Government Mohan Kumaramangalam Medical College Hospital, Shevapet, Salem, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM) and genetic variants like RAGE -374T/A may influence disease susceptibility. Therefore, it is of interest to analyze the association between RAGE -374T/A polymorphism and DN in T2DM patients from Kolar, Karnataka. Genotyping was done by PCR-RFLP and clinical parameters were compared. No significant association was found between the polymorphism and DN (p > 0.05), though DN patients showed elevated HbA1c, microalbuminuria and dyslipidemia. These findings suggest metabolic factors, rather than this specific RAGE variant, are more strongly linked to DN risk in this population.

Indexed as

Blood parametersgene polymorphismglycemic indexRage gene

Identifiers

PMID41393436
PMCPMC12697405

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