Evidence map›Paper›PMID 41393280›Full record

ArticleFrontiers in endocrinology2025

CU Cilia - an application for image analysis by machine learning - reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells.

Maren Rehders, Kseniia Alekseitseva, João Gissoni, Alara G Doğru, Petr Popov, Andrei Boiarov, Klaudia Brix

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maren RehdersSchool of Science, Constructor University, Bremen, Germany.
Kseniia AlekseitsevaConstructor Technology AG, Schaffhausen, Switzerland.
João GissoniSchool of Science, Constructor University, Bremen, Germany.
Alara G DoğruSchool of Science, Constructor University, Bremen, Germany.
Petr PopovSchool of Science, Constructor University, Bremen, Germany.
Andrei BoiarovConstructor Technology AG, Schaffhausen, Switzerland.
Klaudia BrixSchool of Science, Constructor University, Bremen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells Methods: In this study, we used an Results: Therefore, we developed CU Cilia, Discussion: The results point to an elongation of primary cilia in the Odanacatib-treated Nthy-ori 3-1 thyroid epithelial cells, supporting the notion that cysteine cathepsin K activity is physiologically important not only in murine but also in human thyroid cells.

Indexed as

Cathepsin KCiliaImage Processing, Computer-AssistedMachine LearningThyroid Epithelial CellsCell LineHumansCathepsin KCTSK protein, humancysteine cathepsinsimage analysismachine learningneural network pre-trainingodanacatibprimary ciliaprotease inhibitorsthyroid epithelial cells

Identifiers

PMID41393280
PMCPMC12695601

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.