ArticleFrontiers in medicine2025
Dysregulated levels of proangiogenic proteins in the placentas of children with autism spectrum disorder and attention-deficit hyperactivity disorder.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comprehensive Analysis of the Placenta-Cortex Transcriptomic Database Reveals a Neuroactive Ligand-Receptor Dysregulation After Prenatal Alcohol Exposure.International journal of molecular sciences · 2026Article
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6 authors.
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Abstract
Placental vascularization may influence fetal brain development, but its long-term impact on neurodevelopment remains unclear. In this pilot study, we analyzed two ligand proteins: vascular endothelial growth factor (VEGF) and placental growth factor (PLGF), and their receptors mRNA and protein levels in placentas from children who later were diagnosed with autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), or controls. ASD placentas showed lower VEGF, PLGF, and KDR protein levels but higher FLT1, while ADHD placentas had increased FLT1 and reduced VEGF mRNA. These findings suggest distinct placental vascular alterations in ASD and ADHD, highlighting a potential role of the placenta-brain axis in neurodevelopmental disorders and early-life mechanisms underlying impaired brain development.
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