Evidence map›Paper›PMID 41393121›Full record

ArticleFrontiers in medicine2025

The left DTI-ALPS index: a potential glymphatic mediator of cognitive and motor dysfunction in Parkinson's disease.

Yanyan Li, Jian Song, Yuqing Zhao, Zengru Lin, Xingduo Pan, Ming Li, Xiaoyan Zhou, Zhen Zhang, Wei Wei, Xiehua Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanyan Li *Department of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Jian Song *Department of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yuqing ZhaoDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Zengru LinDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Xingduo PanDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Ming LiDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Xiaoyan ZhouDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Zhen ZhangDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Wei WeiDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Xiehua XueDepartment of Medical Imaging, The Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study employed the Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) index to evaluate glymphatic function in patients with Parkinson's disease (PD) and investigated its association with cognitive and motor functions. Methods: Clinical data from the PD group ( Results: Compared with the HC group, the PD group exhibited increased diffusivity of both the left projection (Dzzproj) and association fibers (Dzzassoc) along the Conclusion: Abnormalities in the left DTI-ALPS index and diffusivity reflect underlying glymphatic system (GS) dysfunction and white matter microstructural damage in PD patients. These neuropathological changes are significantly associated with, and collectively contribute to, the progression of motor and cognitive decline. Furthermore, the left DTI-ALPS index shows promise as a novel biomarker for identifying cognitive impairment in PD patients.

Indexed as

cognitive functionDiffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS)magnetic resonance imaging (MRI)motor functionParkinson’s disease

Identifiers

PMID41393121
PMCPMC12698549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.