ReviewFrontiers in medicine2025
Recent advancements in smart responsive tissue adhesives for medical applications.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Bioadhesive Hydrogels for Tissue Repair: Design Strategies, Adhesion Mechanisms, and Emerging Applications.Molecules (Basel, Switzerland) · 2026Review
- Shape memory polymer adhesives for on-demand, low-force detachment in skin-interfaced devices.Nature communications · 2026Article
- Programmable Hydrogels for Surgical Interface Control: Function-Based Design, DNA-Based Molecular Modules, and Translational Evaluation.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioadhesives have emerged as a promising alternative to conventional sutures, offering rapid and robust tissue integration while overcoming limitations such as time-consuming procedures and risks of secondary tissue damage. However, the bonding strength and degradation kinetics of most existing adhesives remain difficult to precisely control, limiting their adaptability to diverse tissue types and clinical scenarios. In this context, smart responsive bioadhesives have attracted significant attention due to their tunable adhesion properties, on-demand detachment capability, and tissue-matching mechanical properties. These materials can respond to biological environmental stimuli, enabling dynamic interactions with biological systems and opening new avenues for applications in wearable devices, controlled drug delivery, tissue repair, and smart bioelectronic interfaces. Nevertheless, a systematic review summarizing the synthesis strategies, adhesion mechanisms, and application prospects of such advanced adhesives remains lacking. Herein, we comprehensively analyzes the design strategies, working principles, and biomedical applications of smart responsive adhesives over the past decade. Furthermore, we discuss current limitations and propose future directions aimed at accelerating the translation of smart responsive adhesives from laboratory research to clinical practice. This review aims to provide a comprehensive understanding of these materials and offer valuable insights for researchers engaged in developing advanced tissue adhesives for practical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.